554. Does Protease Inhibitor (PI) Monotherapy Select Primary PI Resistance?
نویسندگان
چکیده
منابع مشابه
Protease inhibitor (Pi) phenotypes in chromosome aberrations.
Many enzymes and several enzyme inhibitors are found in multiple molecular forms in different human populations. Some of them constitute important polymorphic systems useful for populations genetics, forensic medicine, and chromosome mapping. However, little is known about the distribution ofthese genetic markers in patients with chrosome aberrations and their parents. The purpose ofthe present...
متن کاملJE-2147: a dipeptide protease inhibitor (PI) that potently inhibits multi-PI-resistant HIV-1.
We designed, synthesized, and identified JE-2147, an allophenylnorstatine-containing dipeptide HIV protease inhibitor (PI), which is potent against a wide spectrum of HIV-1, HIV-2, simian immunodeficiency virus, and various clinical HIV-1 strains in vitro. Drug-resistant clinical HIV-1 strains, isolated from seven patients who had failed 9-11 different anti-HIV therapeutics after 32-83 months, ...
متن کاملPersistence of HIV-1 variants with multiple protease inhibitor (PI)-resistance mutations in the absence of PI therapy can be explained by compensatory fixation.
OBJECTIVE To investigate the mechanism explaining the persistence of human immunodeficiency virus (HIV) type 1 variants with multiple protease inhibitor (PI)-resistance mutations in the absence of PI therapy. METHODS Longitudinal genotypic analyses were performed on sequential samples obtained from 2 HIV-1-infected patients who had stopped PI therapy for 4 years. Replication capacity (RC) was...
متن کاملThe state of PI monotherapy and NRTI-sparing therapy
Current consensus about treatment of HIV infection is that HAART must include two nucleoside reverse transcriptase inhibitors plus a third drug (one non-nucleoside reverse transcriptase inhibitor, a boosted protease inhibitor, an integrase strand transfer inhibitor and possibly a CCR5 inhibitor). There is a lot of interest about changing the basic structure of the antiretroviral regimen so we c...
متن کاملDalitz plot analysis of the D+->pi(-)pi(+)pi(+) decay
G. Bonvicini, D. Cinabro, M. Dubrovin, A. Lincoln, D. M. Asner, K. W. Edwards, P. Naik, R. A. Briere, T. Ferguson, G. Tatishvili, H. Vogel, M. E. Watkins, J. L. Rosner, N. E. Adam, J. P. Alexander, D. G. Cassel, J. E. Duboscq, R. Ehrlich, L. Fields, R. S. Galik, L. Gibbons, R. Gray, S. W. Gray, D. L. Hartill, B. K. Heltsley, D. Hertz, C. D. Jones, J. Kandaswamy, D. L. Kreinick, V. E. Kuznetsov,...
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ژورنال
عنوان ژورنال: Open Forum Infectious Diseases
سال: 2018
ISSN: 2328-8957
DOI: 10.1093/ofid/ofy210.562